By Jack J. Pasternak
An advent to Human Molecular Genetics
Jack J. Pasternak
the second one variation of this across the world acclaimed textual content expands its assurance of the molecular genetics of inherited human ailments with the most recent learn findings and discoveries. utilizing a different, systems-based method, the textual content deals readers a radical clarification of the gene discovery approach and the way faulty genes are associated with inherited sickness states in significant organ and tissue structures. the entire most modern advancements in useful genomics, proteomics, and microarray expertise were completely integrated into the text.
the 1st a part of the textual content introduces readers to the basics of cytogenetics and Mendelian genetics. subsequent, ideas and techniques for gene manipulation, mapping, and isolation are tested. Readers will fairly relish the text's incredibly thorough and transparent rationalization of genetic mapping. the ultimate half beneficial properties designated insurance of the molecular genetics of precise organic structures, overlaying muscle, neurological, eye, melanoma, and mitochondrial issues. through the textual content, necessary figures and diagrams illustrate and make clear advanced material.
Readers conversant in the 1st variation will realize the text's comparable lucid and fascinating variety, and may discover a wealth of recent and extended fabric that brings them absolutely modern with a present knowing of the sector, including:
* New chapters on complicated genetic problems, genomic imprinting, and human inhabitants genetics
* improved and entirely revised part on medical genetics, masking diagnostic checking out, molecular screening, and numerous treatments
this article is focused at upper-level undergraduate scholars, graduate scholars, and clinical scholars. it's also a very good reference for researchers and physicians who desire a clinically correct reference for the molecular genetics of inherited human diseases.Content:
Chapter 1 realizing Human ailment (pages 1–18):
Chapter 2 The Genetic method: Chromosomes (pages 19–36):
Chapter three The Genetic method: Mendel's legislation of Inheritance and Genetic Linkage (pages 37–74):
Chapter four The Molecular Biology of the Gene (pages 75–106):
Chapter five Recombinant DNA expertise (pages 107–152):
Chapter 6 Genetic and actual Mapping of the Human Genome (pages 153–188):
Chapter 7 researching Human sickness Genes (pages 189–202):
Chapter eight Bioinformatics: Genomics, sensible Genomics, and Proteomics (pages 203–228):
Chapter nine Human inhabitants Genetics (pages 229–294):
Chapter 10 Molecular Genetics of complicated problems (pages 295–331):
Chapter eleven Genomic Imprinting: An Epigenetic amendment (pages 333–348):
Chapter 12 Molecular Genetics of Mitochondrial issues (pages 349–368):
Chapter thirteen Molecular Genetics of Muscle problems (pages 369–392):
Chapter 14 Molecular Genetics of Neurological issues (pages 393–437):
Chapter 15 Molecular Genetics of the attention (pages 439–470):
Chapter sixteen Molecular Genetics of melanoma Syndromes (pages 471–516):
Chapter 17 Counseling, Diagnostic checking out, and administration of Genetic issues (pages 517–556):
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Extra info for An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases, Second Edition
Mentor Books, Toronto, Canada. Shannon, T. W. 1917. Eugenics or the Laws of Sex Life and Heredity. S. A. Mullikin, Marietta, OH. q u e s t i o n s 6. What is the rationale for studying genetic traits in twins? 7. Describe why a condition that appears to “run in a family” is not necessarily genetically determined. 8. Who were the first people to record an inherited defect within a family? Describe in detail the features of the pattern of inheritance they observed. What is sickle cell anemia? How did the study of the cause of this disease play a role in the understanding of the molecular basis of genetic diseases?
And, by necessity, we have sought ways to control the disastrous impact that disease can have on our lives. With the discovery in the late nineteenth century that many diseases were caused by microorganisms, both the treatment and management of these scourges became possible. The addition of vaccines and drugs in the twentieth century brought most of these diseases under total control. Consequently, biological disorders of the heart and circulatory system, cancers, and a variety of genetic disorders have now become major concerns.
1982. The Growth of Biological Thought: Diversity, Evolution and Inheritance. Harvard University Press, Cambridge, MA. McKeown, T. 1988. The Origins of Human Disease. , Oxford. Métraux, G. S. and F. ). 1963. The Nineteenth Century World. Mentor Books, Toronto, Canada. Shannon, T. W. 1917. Eugenics or the Laws of Sex Life and Heredity. S. A. Mullikin, Marietta, OH. q u e s t i o n s 6. What is the rationale for studying genetic traits in twins? 7. Describe why a condition that appears to “run in a family” is not necessarily genetically determined.
An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases, Second Edition by Jack J. Pasternak