By René H. Levy, Richard H. Mattson, Brian S. Meldrum, Emilio Perucca
The completely revised, up-to-date 5th version of this vintage is the main complete, present, and authoritative reference on all anticonvulsants to be had this day. This variation gains distinctive profiles of more recent drugs--including levetiracetam, oxcarbazepine, tiagabine, topiramate, and zonisamide--and new chapters on use of antiepileptic medicines in teenagers and through pregnancy.Drugs are lined in alphabetical order and in an easy-to-follow layout: mechanisms of motion; chemistry, biotransformation, and pharmacokinetics; interactions; scientific efficacy and use; and opposed results. assurance of scientific use comprises nonepileptic and psychiatric issues the place acceptable. This variation has been trimmed to conceivable dimension through shortening chapters on older, much less often used medications.
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Extra info for Antiepileptic Drugs, 5th Edition
Krauss et al. (106) studied four patients treated with vigabatrin for 2 to 40 months who experienced symptoms of visual field constriction or blurring. All had evidence of retinal dysfunction on electroretinography (ERG). Two had normal VEPs, one had prolonged VEP latency, and one had normal latencies but decreased P1 amplitude. In another study involving 39 asymptomatic patients who had taken vigabatrin for an average of 52 months (range, 28 to 78 months), 7 (18%) had bilaterally delayed VEPs; 5 of these also had reduced amplitudes (109).
Cellular mechanisms of epilepsy: a status report. Science 1987;237:157-164. 3. Avoli M, Rogawski MA, Avanzini G. Generalized epileptic disorders: an update. Epilepsia 2001;42:445-457. 4. Rogawski MA. Mechanism-specific pathways for new antiepileptic drug discovery. In: French JA, Leppik IE, Dichter MA, eds. Antiepileptic drug development. Philadelphia: Lippincott-Raven, 1998:1-27. 5. Rogawski MA. KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci 2000;23:393-398.
Adapted from Ahmad S, Perucca E, Richens A. The effects of furosemide, mexiletine, (+)propranolol and three benzodiazepine drugs on interictal spike discharges in the electroencephalogram of epileptic patients. Br J Clin Pharmacol 1977;4: 683-688, with permission). The effects of AEDs on EEG epileptiform activity are discussed in the following sections for each major agent or class of agents. Benzodiazepines Benzodiazepines are potent AEDs when administered acutely and act rapidly to suppress interictal and ictal EEG discharges.
Antiepileptic Drugs, 5th Edition by René H. Levy, Richard H. Mattson, Brian S. Meldrum, Emilio Perucca